Scientists would not ever have become captivated with strawberries if it wasn't for this plant pigment. Meet fisetin a promising anti-aging compound and a so-called senolytic. It has anti-inflammatory, antioxidant, and immune-supporting properties!
Fisetin gives color to many different fruits and veggies. Fisetin like resveratrol and quercetin is a flavonol with antioxidant properties. Science teams are presently exploring its ability to slow the aging process and extend life expectancy.
There are appealing animal and cell-based studies showing that fisetin may be able to protect the brain and enhance memory, delay aging, helps manage blood sugar, and have anti-cancer properties. It also shows promise for protecting the liver as well as the heart.
Fisetin's prospective anti-aging results are exciting however will need to wait and see if they will be validated in human trials. Checking the reviews on Amazon and Double Wood is showing great promise in the benefit of this supplement.
Fisetin and Inflammation
If you’re looking to increase your consumption of anti-inflammatory foods, start reaching for those strawberries. Fisetin has proved to possess strong anti-inflammatory effects in cell culture and in animal models relevant to human diseases, according to research published in Advances in Experimental Medicine and Biology.
Clear Away Senescent Cells
By removing senescent cells. What are senescent cells? Senescent cells are cells that have reached an age where they no longer divide. If they are not removed they can build up in tissue throughout the body and release harmful substances that cause inflammation and damage to healthy cells. Fisetin has been shown to calm inflammation, improve physical function, and increases lifespan in animals and researchers are excited about what it may be able to do for humans.
Fisetin is able to destroy senescent cells without harming healthy cells. In a 2018 cell-based study of 10 compounds known to destroy senescent cells, fisetin was the most effective one. In old mice, fisetin cleared senescent cells and increased their lifespan by over 10%.
In one study Fisetin slowed the progression of cataracts and protected the kidneys of diabetic mice by blocking inflammation and oxidative stress. It also protected the liver of diabetic rats from high blood sugar levels by increasing antioxidant levels.
A clinical trial are now underway to see if fisetin is effective for reducing inflammation and improving frailty and bone health in elderly people.
Research shows that fisetin may help promote cardiovascular health. One study reports that the antioxidant properties can induce cardiac regeneration by activating genes involved in cell proliferation. This may protect the heart from ischemic damage following a heart attack.
There’s some evidence that fisetin may help prevent stroke as well. An animal study found that fisetin, quercetin, and aspirin showed significant prolongation of clotting time and thrombin time.
Aging and Memory
As we age, some immune cells found in the brain become overactive. This brings on inflammation and damages healthy brain cells.
Laboratory studies have found that fisetin helps boost the levels of antioxidants in the brain and prevents the release of inflammatory compounds.
Animal studies have also found that fisetin reduces the build-up of amyloid plaque in mice and protects against the loss of healthy brain cells. Fisetin also reduced depression, increased noradrenaline and serotonin levels in animal studies.
Researchers also found that this reduced anxiety and depression caused by pain. They think that fisetin blocks an enzyme that breaks down noradrenaline and serotonin.
Fisetin and Inflammation
The compound has been reported to elicit antioxidant and anti-inflammatory effects, retard the development of atherosclerosis, and exhibit neuroprotective properties in several preclinical studies. One study showed that fisetin inhibited inflammation-related cytokines and the angiogenic factor in rheumatoid arthritic fibroblasts.
Data suggest that fisetin possesses antiproliferative properties against several cancers, which means that it may inhibit tumor cell growth. Researchers believe that it has potential value in cancer prevention and treatment, as it may reduce angiogenesis (the growth of new blood vessels) and suppress tumor growth.